HOW IMMUNE THERAPY HELPS
Dr. Hari Krishna claims sometimes, a patient's immune system will not recognize cancer cells as foreign
because the cancer cells' antigens are not different enough from those of normal cells to cause an immune
reaction. Or, the immune system may recognize cancer cells, but provides a response that is not strong
enough to destroy the cancer. Various kinds of immunotherapies have been designed to help the immune
system recognize cancer cells as a target for attack, and to strengthen the attack so that it will destroy the
cancer.
TYPES OF IMMUNOTHERAPY
Dr. Krishna strongly says that immunotherapies can be divided into several broad categories:
· Nonspecific immunotherapies and adjuvants
· Active specific immunotherapies (cancer vaccines)
· Passive immunotherapies (monoclonal antibodies)
Sometimes, doctors will use two or more of these immunotherapy options together. Some tumors are more
effectively attacked by one kind of immune system cell than another, so doctors and researchers use that
knowledge when designing and applying immunotherapies.
CANCER VACCINES (ACTIVE SPECIFIC IMMUNOTHERAPIES)
People are most familiar with vaccines that use weakened or killed viruses, bacteria, or other germs, and are
given to healthy people to prevent an infectious disease. Doctors knew by the early 1800's that smallpox, a
serious disease of humans, could be prevented by intentionally exposing a person to a virus that caused a
similar disease of cows, known as cowpox. Because the Latin word for cow is vacca , the cowpox virus
was named vaccinia , and the process of intentionally exposing people to a disease to prevent more serious
one became known as vaccination.
A cancer vaccine contains cancer cells, parts of cells, or chemically pure antigens and causes increased
immune response against cancer cells present in the patient's body. Cancer vaccines are considered active
immunotherapies, because substances are injected into the patient that are meant to trigger an active
response by the patient's own immune system. Cancer vaccines cause the immune system to produce
antibodies to one or several antigens, and/or to produce cytotoxic T lymphocytes to attack cancer cells that
have those antigens. Vaccines may also be combined with nonspecific immunotherapy using additional
substances or cells called adjuvants, to boost the immune response.
TUMOR CELL VACCINES
These vaccines use cancer cells obtained either from the patient being treated or from another patient. The
tumor cells are killed, usually by radiation, before they are injected into the patient so that they cannot form
more tumors. But, antigens on the tumor cell surfaces are still there, and they stimulate a specific immune
system response. As a result, the patient's cancer cells carrying these antigens are recognized and attacked.
Doctors may also mix the dead tumor cells with other substances known to increase the immune response.
These substances are referred to as non-specific adjuvants, meaning that the general boost they give to the
immune system is meant to improve the effectiveness of the vaccine.
Dr. Krishna recommended one reason for using whole tumor cells in vaccines, instead of individual antigens,
is that not all cancer antigens have been identified yet. Using the whole tumor cell may expose the patient's
immune system to a large number of antigens, including some that could not be produced and injected
separately because they have not yet been discovered.
When the patient's own tumor cells are used to create a vaccine, these cells typically do not cause a strong
immune response to begin with and may even give off substances that suppress the immune system.
Researchers have sought to overcome those problems by altering the patient's tumor cells before reinjecting
them. This may involve treatments with certain chemicals that alter substances on the cell surface, or the
addition of specific DNA sequences that instruct the tumor cells to produce new substances that attract
immune system cells. Cytokines (natural immune system hormones) that stimulate activity of immune system
cells may be able to counteract the actions of the substances tumors give off to suppress the immune system.
Researchers may treat patients with some cytokines as part of the vaccine process, and are looking at ways
to get the body to produce more of those cytokines.
Because of the difficulty in making a new autologous vaccine for every patient, researchers looked at ways
to create tumor cell vaccines that could be effective in any patient with a particular kind of cancer. One way
of doing that is to use cells grown in the lab from a cancer originally removed from another patient. Those
allogenic cells are killed and given to the patient, usually along with one or more adjuvant substances known
to stimulate the growth or activity of immune system cells.
Tumor cell vaccines are being studied for use against several cancers, including melanoma, ovarian cancer,
prostate cancer, breast cancer, colorectal cancer, lung cancer, liver cancer, non Hodgkin's lymphoma,
stomach cancer, nasopharyngeal carcinoma and astrocytoma etc.
Cancer-Healer medicine is working successfully in this aspect
ANTIGEN VACCINE FOR HEREDITY CANCER
Antigen vaccines stimulate the immune system by using individual antigens rather than using whole tumor
cells that contain many thousands of antigens. Scientists have recently discovered the genetic codes of many
antigens. By using gene-splicing techniques, they can mass-produce these antigens in the lab. Or, some
antigens can now be made entirely from synthetic chemicals. When these antigens are produced in the lab,
scientists can change them in ways that make them more easily recognized by the immune system's cells.
Dr. Hari Krishna says, like Cancer-Healer his new technology means that large amounts of these very
specific antigens can now be given to many patients. We know that some antigens cause an immune
response in patients with certain cancers. Others produce immune reactions to more than one kind of cancer.
Often scientists combine several antigens in each vaccine to cause a response to more than one of the
antigens that may be present on cancer cells.
Antigen vaccines are being studied in patients with breast cancer, colorectal cancer, ovarian cancer,
melanoma, pancreatic cancer, and other cancers.
Cancer-Healer medicine is working same as antigen vaccine & stops heredity cancer
DNA VACCINES
When antigens are injected into the body as a vaccine, they may produce the desired immune response at
first, but often are less effective over time because antibodies rapidly attach to them and immune system cells
destroy them. So, scientists have looked for a way to provide a steady supply of antigens to stimulate an
ongoing immune response.
Deoxyribonucleic acid, or DNA, is the material in the nucleus (center) of cells that contains the genetic code
for proteins that cells produce. Instead of injecting antigens into the patient, scientists can now inject bits of
DNA that instruct the patient's cells to continuously produce certain antigens. These therapies are called
DNA vaccines. Scientists may also remove cells from the patient, which are returned to the patient after
being treated with DNA containing instructions on making a particular antigen. The altered cell then produces
the antigen on an ongoing basis to keep the immune response strong.
Researchers have learned to use the tools of recombinant DNA technology ("gene splicing") to do the same
thing with substances other than tumor antigens (cytokines, for example). Not all immunotherapies using
DNA are vaccines, technically speaking, but their goals are all the same -- a steady supply of whatever
substance is being used to stimulate the immune system. And, not all treatments using DNA are
immunotherapies. Other types of gene therapy replace the damaged genes responsible for the cancer cell's
abnormal growth, or add new genes that make the cancer cells more sensitive to anticancer drugs.
Dr. Hari Krishna claims sometimes, a patient's immune system will not recognize cancer cells as foreign
because the cancer cells' antigens are not different enough from those of normal cells to cause an immune
reaction. Or, the immune system may recognize cancer cells, but provides a response that is not strong
enough to destroy the cancer. Various kinds of immunotherapies have been designed to help the immune
system recognize cancer cells as a target for attack, and to strengthen the attack so that it will destroy the
cancer.
TYPES OF IMMUNOTHERAPY
Dr. Krishna strongly says that immunotherapies can be divided into several broad categories:
· Nonspecific immunotherapies and adjuvants
· Active specific immunotherapies (cancer vaccines)
· Passive immunotherapies (monoclonal antibodies)
Sometimes, doctors will use two or more of these immunotherapy options together. Some tumors are more
effectively attacked by one kind of immune system cell than another, so doctors and researchers use that
knowledge when designing and applying immunotherapies.
CANCER VACCINES (ACTIVE SPECIFIC IMMUNOTHERAPIES)
People are most familiar with vaccines that use weakened or killed viruses, bacteria, or other germs, and are
given to healthy people to prevent an infectious disease. Doctors knew by the early 1800's that smallpox, a
serious disease of humans, could be prevented by intentionally exposing a person to a virus that caused a
similar disease of cows, known as cowpox. Because the Latin word for cow is vacca , the cowpox virus
was named vaccinia , and the process of intentionally exposing people to a disease to prevent more serious
one became known as vaccination.
A cancer vaccine contains cancer cells, parts of cells, or chemically pure antigens and causes increased
immune response against cancer cells present in the patient's body. Cancer vaccines are considered active
immunotherapies, because substances are injected into the patient that are meant to trigger an active
response by the patient's own immune system. Cancer vaccines cause the immune system to produce
antibodies to one or several antigens, and/or to produce cytotoxic T lymphocytes to attack cancer cells that
have those antigens. Vaccines may also be combined with nonspecific immunotherapy using additional
substances or cells called adjuvants, to boost the immune response.
TUMOR CELL VACCINES
These vaccines use cancer cells obtained either from the patient being treated or from another patient. The
tumor cells are killed, usually by radiation, before they are injected into the patient so that they cannot form
more tumors. But, antigens on the tumor cell surfaces are still there, and they stimulate a specific immune
system response. As a result, the patient's cancer cells carrying these antigens are recognized and attacked.
Doctors may also mix the dead tumor cells with other substances known to increase the immune response.
These substances are referred to as non-specific adjuvants, meaning that the general boost they give to the
immune system is meant to improve the effectiveness of the vaccine.
Dr. Krishna recommended one reason for using whole tumor cells in vaccines, instead of individual antigens,
is that not all cancer antigens have been identified yet. Using the whole tumor cell may expose the patient's
immune system to a large number of antigens, including some that could not be produced and injected
separately because they have not yet been discovered.
When the patient's own tumor cells are used to create a vaccine, these cells typically do not cause a strong
immune response to begin with and may even give off substances that suppress the immune system.
Researchers have sought to overcome those problems by altering the patient's tumor cells before reinjecting
them. This may involve treatments with certain chemicals that alter substances on the cell surface, or the
addition of specific DNA sequences that instruct the tumor cells to produce new substances that attract
immune system cells. Cytokines (natural immune system hormones) that stimulate activity of immune system
cells may be able to counteract the actions of the substances tumors give off to suppress the immune system.
Researchers may treat patients with some cytokines as part of the vaccine process, and are looking at ways
to get the body to produce more of those cytokines.
Because of the difficulty in making a new autologous vaccine for every patient, researchers looked at ways
to create tumor cell vaccines that could be effective in any patient with a particular kind of cancer. One way
of doing that is to use cells grown in the lab from a cancer originally removed from another patient. Those
allogenic cells are killed and given to the patient, usually along with one or more adjuvant substances known
to stimulate the growth or activity of immune system cells.
Tumor cell vaccines are being studied for use against several cancers, including melanoma, ovarian cancer,
prostate cancer, breast cancer, colorectal cancer, lung cancer, liver cancer, non Hodgkin's lymphoma,
stomach cancer, nasopharyngeal carcinoma and astrocytoma etc.
Cancer-Healer medicine is working successfully in this aspect
ANTIGEN VACCINE FOR HEREDITY CANCER
Antigen vaccines stimulate the immune system by using individual antigens rather than using whole tumor
cells that contain many thousands of antigens. Scientists have recently discovered the genetic codes of many
antigens. By using gene-splicing techniques, they can mass-produce these antigens in the lab. Or, some
antigens can now be made entirely from synthetic chemicals. When these antigens are produced in the lab,
scientists can change them in ways that make them more easily recognized by the immune system's cells.
Dr. Hari Krishna says, like Cancer-Healer his new technology means that large amounts of these very
specific antigens can now be given to many patients. We know that some antigens cause an immune
response in patients with certain cancers. Others produce immune reactions to more than one kind of cancer.
Often scientists combine several antigens in each vaccine to cause a response to more than one of the
antigens that may be present on cancer cells.
Antigen vaccines are being studied in patients with breast cancer, colorectal cancer, ovarian cancer,
melanoma, pancreatic cancer, and other cancers.
Cancer-Healer medicine is working same as antigen vaccine & stops heredity cancer
DNA VACCINES
When antigens are injected into the body as a vaccine, they may produce the desired immune response at
first, but often are less effective over time because antibodies rapidly attach to them and immune system cells
destroy them. So, scientists have looked for a way to provide a steady supply of antigens to stimulate an
ongoing immune response.
Deoxyribonucleic acid, or DNA, is the material in the nucleus (center) of cells that contains the genetic code
for proteins that cells produce. Instead of injecting antigens into the patient, scientists can now inject bits of
DNA that instruct the patient's cells to continuously produce certain antigens. These therapies are called
DNA vaccines. Scientists may also remove cells from the patient, which are returned to the patient after
being treated with DNA containing instructions on making a particular antigen. The altered cell then produces
the antigen on an ongoing basis to keep the immune response strong.
Researchers have learned to use the tools of recombinant DNA technology ("gene splicing") to do the same
thing with substances other than tumor antigens (cytokines, for example). Not all immunotherapies using
DNA are vaccines, technically speaking, but their goals are all the same -- a steady supply of whatever
substance is being used to stimulate the immune system. And, not all treatments using DNA are
immunotherapies. Other types of gene therapy replace the damaged genes responsible for the cancer cell's
abnormal growth, or add new genes that make the cancer cells more sensitive to anticancer drugs.
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